【Book】A book chapter has been published by Springer Nature Singapore

The book chapter provides an overview of research findings on the separation and detection of biomarkers through the integration of oxide nanowires and microfluidic devices, highlighting their potential applications in cancer diagnosis.

Book chapter summary
Liquid biopsy has emerged as an innovative diagnostic method for analyzing cancer-related biomarkers in bodily fluids, offering a non-invasive and dynamic approach for cancer detection and monitoring. However, its practical application faces challenges due to the complexities involved in the collection, separation, and detection of cancer-related biomarkers in bodily fluids. Microfluidic systems integrated with nanostructures present a promising platform to overcome these obstacles. Nanostructures, with their high surface-to-volume ratio, are expected to interact effectively with biomarkers. In particular, oxide nanowires, with their unique properties such as surface charge and specific nanoarchitecture, are considered well-suited for biomarker analysis. This chapter provides an overview of research conducted in our laboratory on biomarker analysis using oxide nanowire-based devices and their potential for cancer diagnosis. The chapter consists of five sections: (1) Introduction, (2) Fabrication of Oxide Nanowires, (3) Nanowire Devices for Biomarker Separation, (4) Nanowire Devices for Biomarker Detection Towards Cancer Diagnosis, and (5) Conclusion.

Book information
Oxide Nanowire-Based Devices for Biomolecule Analysis Towards Cancer Diagnosis
Z. Zhu and T. Yasui
in Applications of Microfluidic Systems in Biology and Medicine, ed. M. Tokeshi, Springer Nature Singapore, 521-561 (2024), 10.1007/978-981-97-6540-9_15.

About Applications of Microfluidic Systems in Biology and Medicine
“Applications of Microfluidic Systems in Biology and Medicine” is a book edited by Professor Manabu Tokeshi from Hokkaido University, which includes the following content. The publisher is Springer Nature Singapore.
・Offers a quick overview of state-of-the-art microfluidic research for medical and biological applications
・Shows what medical and biological applications are possible with the use of microfluidic devices
・Presents a variety of latest important related topics