A paper has been published by Chemical Communications

This study focuses on the development of a nanowire device with low cytotoxicity that effectively removes extracellular vesicles derived from cancer cells. We have been selected for the front cover.

Paper summary
Extracellular vesicles (EVs) play a crucial role in cancer cell proliferation and metastasis, and are known to induce abnormal growth in normal cells. In this study, we developed EV removal devices using zinc oxide (ZnO) nanowires and core-shell nanowires coated with titanium dioxide (TiO2) or silicon dioxide (SiO2) layers. These nanowires possess distinct surface charges, enabling them to efficiently remove different types of EVs. Among them, ZnO/SiO2 core-shell nanowires demonstrated the ability to eliminate EVs without causing cytotoxicity. Comparative studies involving the culture of normal cells in media supplemented with cancer-derived EVs and in media where cancer-derived EVs were removed by the device revealed that removing cancer-derived EVs suppressed abnormal cell proliferation in normal cells. This technology holds potential for inhibiting cancer metastasis and contributing to the development of novel therapeutic strategies.

Article information
Non-toxic core-shell nanowires for in vitro extracellular vesicle scavenging
Piyawan Paisrisarn, Kunanon Chattrairat*, Yuta Nakamura, Kazuki Nagashima, Takeshi Yanagida, Yoshinobu Baba*, and Takao Yasui*
Chemical Communications (2025), DOI: 10.1039/d4cc03767g

Chemical Communications
Chemical Communications is a journal that publishes urgent and significant new research of high interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Its 4-page Communication articles allow researchers to report noteworthy findings even at the early stages of investigation. The journal covers all areas of chemistry and interdisciplinary research at the interface of chemistry and other fields, such as materials science, nanoscience, physics, engineering, and biology, particularly when significant novelty in the chemistry aspects is demonstrated. Key topic areas include analytical chemistry, catalysis, chemical biology and medicinal chemistry, computational chemistry and machine learning, energy, green chemistry, inorganic chemistry, materials chemistry, nanoscience, organic chemistry, physical chemistry, polymer chemistry, and supramolecular chemistry.